5-Amino-1MQ

5-Amino-1MQ is a small molecule compound classified as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). In laboratory models, it has been studied for its effects on cellular energy metabolism, lipogenesis, and adipocyte differentiation pathways. Research suggests it may modulate NAD+ salvage pathways by reducing NNMT activity in cellular assays.

5-Amino-1MQ is a research-grade small molecule that selectively inhibits nicotinamide N-methyltransferase (NNMT). It is studied in laboratory settings for its role in NAD+ metabolism, cellular energy regulation, and lipid biosynthesis pathways. This compound is supplied as a lyophilized powder for reconstitution in research applications.

5-Amino-1MQ was identified through structure-activity relationship studies targeting NNMT, an enzyme involved in one-carbon metabolism and NAD+ homeostasis. Early research emerged from academic investigations into metabolic regulation, with published in vitro and in vivo studies characterizing its pharmacological profile beginning in the late 2010s.

In vitro studies have demonstrated that 5-Amino-1MQ inhibits NNMT enzymatic activity, leading to increased intracellular NAD+ levels and reduced lipid accumulation in adipocyte cell lines. Animal model studies have reported alterations in body composition metrics and energy expenditure parameters. Research continues into its selectivity profile and downstream metabolic effects.