SLU-PP-332

SLU-PP-332 is a small molecule agonist of estrogen-related receptors (ERRα, ERRβ, ERRγ), a subfamily of orphan nuclear receptors involved in mitochondrial biogenesis and oxidative metabolism. It is studied in research for its effects on cellular energy metabolism, mitochondrial function, and exercise-mimetic signaling pathways.

SLU-PP-332 is a small molecule pan-agonist of estrogen-related receptors (ERRα/β/γ), orphan nuclear receptors regulating mitochondrial biogenesis and oxidative metabolism. It is studied in research for its exercise-mimetic signaling properties and mitochondrial biology effects. Supplied as a research compound.

SLU-PP-332 was developed by researchers at Saint Louis University (SLU) as part of efforts to identify selective ERR agonists. Its characterization as an ERR pan-agonist with exercise-mimetic properties in preclinical models was published in the 2020s, generating significant interest in nuclear receptor and metabolic biology research communities.

Published preclinical studies demonstrate that SLU-PP-332 activates ERRα, ERRβ, and ERRγ transcriptional programs, upregulating genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation. Animal model studies have reported enhanced mitochondrial content and oxidative capacity markers in skeletal muscle. Research continues into its selectivity profile and downstream metabolic effects.