VIP

VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide belonging to the secretin/glucagon superfamily. It is studied in research for its broad biological activity including vasodilatory, immunomodulatory, and neuromodulatory signaling through VPAC1 and VPAC2 receptors.

VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide that signals through VPAC1/VPAC2 receptors. It is studied in research for its vasodilatory, immunomodulatory, and neuromodulatory properties across multiple organ systems. Supplied as a lyophilized research peptide.

VIP was first isolated from porcine intestine in 1970 by Sami Said and Viktor Mutt. Initially characterized for its vasodilatory properties, subsequent research revealed its widespread distribution throughout the nervous, immune, and endocrine systems. It has been studied for over 50 years as a multifunctional regulatory peptide.

Published research demonstrates that VIP signals through VPAC1 and VPAC2 G-protein coupled receptors, activating cAMP/PKA-dependent signaling cascades. Studies have characterized its effects on smooth muscle relaxation, immune cell modulation (T-cell differentiation, cytokine regulation), circadian rhythm signaling, and neuroprotection. Its role in gastrointestinal, pulmonary, and immune system research continues to expand.